The Children’s Cancer Centre Biobank is a world-class resource for researchers studying childhood and adolescent/young adult (AYA) cancer. The Biobank is based at the Murdoch Children's Research Institute and The Royal Children’s Hospital (RCH). Our Biobank also includes patients with bone marrow disorders, primary immunodeficiency disease and Neurofibromatosis.
Our bank is an incredibly valuable collection of samples such as solid tumour tissue, blood and bone marrow that have been preserved with the utmost care and dignity for future clinical and research purposes.
Samples are collected, processed and placed into storage where they are then made available for further clinical testing and ethically approved research projects such as clinical trials. The ultimate aim is to improve prevention, diagnosis and treatment for children with these conditions.
The CCC Biobank is one of only five paediatric tumour tissue banks in Australia. As the largest centre for the treatment of paediatric cancers in Australia, the campus embodies an exciting opportunity to access rare solid and liquid tumours (such as leukaemia) from paediatric patients during the course of treatment.
The collection of tumour specimens from patients into a highly regulated Biobank is an important aspect of the core business of the Children's Cancer Centre. Our goal is to provide the best care possible for current and future patients and the Biobank is an essential component of this mandate. The CCC Biobank enables clinicians to offer patients participation in international clinical trials. This is achieved by providing tissue, blood and bone marrow processing to facilitate these research efforts.
The Children’s Cancer Centre Biobank was established by and is proudly supported by Cancer in Kids @ RCH (www.cika.org.au) and the Royal Children’s Hospital Foundation. Funds to process blood and bone marrow from patients with leukaemia were provided by the Leukaemia Auxiliary at RCH (LARCH). Funding provided by the Children’s Cancer Foundation and My Room from 2007 to 2013 for the Children's Cancer Tumour Bank supported the collection and storage of tissue samples, providing the core collection for today’s Biobank.
Why is tissue needed for research?
While survival rates from childhood and AYA cancers have improved, research is needed to understand how the disease develops and to investigate the best ways to treat, cure and ultimately prevent the disease from occurring.
This research relies on using tissue samples removed from patients in the operating theatre or in the clinic during the course of clinical investigation and treatment. Unfortunately, researchers are extremely limited in the application of their research to paediatric and AYA cancer due to the lack of high quality samples.
Our Biobank provides these valuable samples for national and international research projects. Without these samples researchers cannot make a difference to improving the outcomes for children and AYA with cancer.
Samples allow researchers to:
- Understand the molecular mechanisms which lead to cancers in children and AYA
- Establish new molecular-based diagnostic tests which will assist with the selection of the most appropriate treatments
- Investigate tumour biology using cell lines
- Test new drugs and therapies before use in the clinic
- Identify new targets for therapy
- Reduce the debilitating side effects of treatment
Donations are a way to make a difference to the fight against cancer now and well into the future as new technologies and advancements become available.
Member of ANZCHOG-BN
The CCC Biobank is a member of the Australian and New Zealand Childrens Heamatology/Oncology Group - Biobanking Network (www.anzchog.org/clinical-trials-research/anzchog-biobanking-network/).
The Australian and New Zealand Children’s Haematology/Oncology Group Biobanking Network. BIOPRESERVATION AND BIOBANKING. Volume 17, Number 2, 2019.