SETIA Program: Surveillance of Enteric Typhoid Fever in Indonesia

Project status: Active

Research areas > Infection, Immunity and Global Health > Enteric Diseases

Economic analyses supporting policy decisions on typhoid conjugate vaccine (TCV) introduction in Indonesia.

Typhoid fever is caused by the bacterium Salmonella enterica serovar Typhi (S. Typhi). Although global incidence has declined over recent decades, typhoid fever remains a public health concern in many countries, including Indonesia.

The program studies will provide evidence to support policy discussions on typhoid vaccination in Indonesia.

The program...

The program studies will provide evidence to support policy discussions on typhoid vaccination in Indonesia.

About the program

The SETIA program examined the economic impact of typhoid illness and evaluated the potential value of introducing typhoid conjugate vaccine (TCV) into Indonesia’s National Immunisation Program.

A multisite cost-of-illness study estimated the direct and indirect costs associated with typhoid fever using data collected from hospitals, primary health centres and households across six provinces in Indonesia, from over 1,500 patients.

These finding were then used to inform economic modelling assessing the potential health and economic outcomes of introducing TCV, including an analysis of the expected budget implications for national immunisation planning.

Together, these studies provide evidence to support policy discussions on typhoid vaccination in Indonesia. The study results will be published in 2026.

Research team and collaborations

SETIA is a collaborative research program led by Murdoch Children’s Research Institute (MCRI) in partnership with Universitas Gadjah Mada in Indonesia.

The MCRI lead investigator is Professor Julie Bines from the Enteric Diseases group.

The studies were supported by the Gates Foundation, USA.