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Dr Maree Faux

Dr Maree Faux

Details

Role Senior Research Officer
Research area Stem Cell Medicine

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Dr Maree Faux is a biochemist and cancer cell biologist, a Senior Research Officer in the Neuro-oncology Group at MCRI and an Honorary Research Fellow in the Department of Surgery, at the University of Melbourne.

Maree’s research aims to understand the biology and biochemical signalling pathways important in normal cell function and the molecular changes that contribute to cancer. Maree’s work has included the discovery of scaffolding complexes that anchor protein kinases and phosphatases to specific subcellular locations and understanding of how truncation of APC in colon tumours affects fundamental cellular processes. She is currently coordinating the developmental biology and cancer research activities in the Neuro-oncology Group. Her research aims to discover new transcriptional regulatory mechanisms and characterise these at the molecular and genomic level in normal development and in childhood cancer.

Over the course of her career, Maree has developed expertise in protein biochemistry and cancer cell biology and has made significant contributions to her field. She is passionate about research discovery and has continually pursued innovative ideas by developing and implementing new procedures to address research question. She is committed to nurturing talent and developing careers through mentoring and supervision of students and colleagues.
Dr Maree Faux is a biochemist and cancer cell biologist, a Senior Research Officer in the Neuro-oncology Group at MCRI and an Honorary Research Fellow in the Department of Surgery, at the University of Melbourne.

Maree’s research aims to understand...
Dr Maree Faux is a biochemist and cancer cell biologist, a Senior Research Officer in the Neuro-oncology Group at MCRI and an Honorary Research Fellow in the Department of Surgery, at the University of Melbourne.

Maree’s research aims to understand the biology and biochemical signalling pathways important in normal cell function and the molecular changes that contribute to cancer. Maree’s work has included the discovery of scaffolding complexes that anchor protein kinases and phosphatases to specific subcellular locations and understanding of how truncation of APC in colon tumours affects fundamental cellular processes. She is currently coordinating the developmental biology and cancer research activities in the Neuro-oncology Group. Her research aims to discover new transcriptional regulatory mechanisms and characterise these at the molecular and genomic level in normal development and in childhood cancer.

Over the course of her career, Maree has developed expertise in protein biochemistry and cancer cell biology and has made significant contributions to her field. She is passionate about research discovery and has continually pursued innovative ideas by developing and implementing new procedures to address research question. She is committed to nurturing talent and developing careers through mentoring and supervision of students and colleagues.

Top Publications

  • Samson, AL, Zhang, Y, Geoghegan, ND, Gavin, XJ, Davies, KA, Mlodzianoski, MJ, Whitehead, LW, Frank, D, Garnish, SE, Fitzgibbon, C, et al. MLKL trafficking and accumulation at the plasma membrane control the kinetics and threshold for necroptosis. Nature Communications 11(1) : 3151 2024
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  • King, LE, Zhang, H-H, Gould, CM, Thomas, DW, Whitehead, LW, Simpson, KJ, Burgess, AW, Faux, MC. Genes regulating membrane-associated E-cadherin and proliferation in adenomatous polyposis coli mutant colon cancer cells: High content siRNA screen. PLOS ONE 15(10) : e0240746 2024
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  • Buchert, M, Athineos, D, Abud, HE, Burke, ZD, Faux, MC, Samuel, MS, Jarnicki, AG, Winbanks, CE, Newton, IP, Meniel, VS, et al. Genetic Dissection of Differential Signaling Threshold Requirements for the Wnt/β-Catenin Pathway In Vivo. PLOS Genetics 6(1) : e1000816 2024
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  • Faux, MC, Coates, JL, Kershaw, NJ, Layton, MJ, Burgess, AW. Independent Interactions of Phosphorylated β-Catenin with E-Cadherin at Cell-Cell Contacts and APC at Cell Protrusions. PLOS ONE 5(11) : e14127 2024
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  • Grohmann, C, Walker, F, Devlin, M, Luo, M-X, Chüeh, AC, Doherty, J, Vaillant, F, Ho, G-Y, Wakefield, MJ, Weeden, CE, et al. Preclinical small molecule WEHI-7326 overcomes drug resistance and elicits response in patient-derived xenograft models of human treatment-refractory tumors. Cell Death & Disease 12(3) : 268 2024
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