A/Prof Shireen Lamande
A/Prof Shireen Lamande
Details
Role
Principal Research Fellow, Lead, Bone &
Research area
Stem cell biology
Group
Musculoskeletal
Human skeletal development and correct bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research aims to understand the molecular basis of these disorders to improve diagnosis and genetic counselling, identify new therapeutic targets and test new treatments to ultimately improve the quality of life for children with these debilitating conditions
Human skeletal development and correct bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s...
Human skeletal development and correct bone, cartilage, joint and muscle function are determined by complex interactions between developmental signalling pathways. Genetic and acquired disorders affecting these tissues are common. The group’s research aims to understand the molecular basis of these disorders to improve diagnosis and genetic counselling, identify new therapeutic targets and test new treatments to ultimately improve the quality of life for children with these debilitating conditions
Top Publications
- Blank, M, McGregor, NE, Rowley, L, Kung, LHW, Crimeen‐Irwin, B, Poulton, IJ, Walker, EC, Gooi, JH, Lamandé, SR, Sims, NA, et al. The effect of carbamazepine on bone structure and strength in control and osteogenesis imperfecta (Col1a2 +/p.G610C) mice. Journal of Cellular and Molecular Medicine 26(14) : 4021 -4031 2022 view publication
- Bateman, JF, Shoulders, MD, Lamandé, SR. Collagen misfolding mutations: the contribution of the unfolded protein response to the molecular pathology. Connective Tissue Research 63(3) : 210 -227 2022 view publication
- Blank, M, McGregor, NE, Rowley, L, Kung, LH, Crimeen-Irwin, B, Poulton, IJ, Walker, EC, Gooi, JH, Lamande, SR, Sims, NA, et al. The effect of carbamazepine on bone structure and strength in control and Osteogenesis Imperfecta (Col1a2 +/p.G610C) mice. 2022 view publication
- Boos, MA, Lamandé, SR, Stok, KS. Multiscale Strain Transfer in Cartilage. Frontiers in Cell and Developmental Biology 10: 795522 2022 view publication
- Woodcock, I, Tachas, G, Desem, N, Houweling, P, Yiu, E, Kean, M, Emmanuel, J, Kennedy, R, Carroll, K, de Valle, K, et al. A Phase 2 open-label study to determine the safety and efficacy of weekly dosing of ATL1102 in patients with non-ambulatory Duchenne muscular dystrophy. 2022 view publication
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