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Dr David Tingay
Dr David Tingay is a clinical neonatologist and respiratory physiologist interested in improving the respiratory outcomes of newborn infants. He is an internationally recognised expert in the physiology of the diseased neonatal lung, particularly the use of advanced modes of mechanical ventilation and imaging regional lung mechanics.
After graduating in Medicine from the University of Adelaide he completed his specialist training in Neonatology and Paediatrics in the UK and Australia. In 2004 he joined the Neonatal Unit of the Royal Children's Hospital as a Staff Specialist. He is also currently a Staff Specialist in the Fetal Management Unit, Royal Women's Hospital and an Honorary Fellow at the University of Melbourne Department of Paediatrics. Dr Tingay was awarded a PhD in 2008 for his thesis on the optimal application of high frequency ventilation. Since then he has been a NHMRC-funded researcher exploring methods of improving the application of mechanical ventilation for sick newborns and children. After completing his PhD he established the Neonatal Respiratory research program at the Murdoch Childrens and is currently the co-leader of the active and successful Murdoch Childrens Neonatal Research Group. This group is one of the few neonatal research groups worldwide with an active and interconnected program of molecular science, translational model research, clinical physiology and engineering research, large clinical trials and developmental long-term follow up. In the last five years Dr Tingay and his group have been investigators involving more than $10 million of successful grant funding.
- NHMRC Research Fellow, Neonatal Research, Clinical Sciences
2013 - 2016: NHMRC Clinical Career Development Fellowship
2008 - 2012: NHMRC Australian Clinical Research Fellowship
2004 - 2007: NHMRC Postgraduate Medical and Dental Research Scholarship
NHMRC Centre of Research Excellence Program
2014 - 2018: Centre of Improving Outcomes of Preterm Birth (CII).
NHMRC Project Grants
2014 - 2016: Optimising lung protective ventilation at birth using the volumetric response of the lung in a preterm lamb model (CIA)
2011 - 2013: Optimising lung protective resuscitation using a newborn premature lamb model (CIA)
2011 - 2013: Consequences of waveform composition for epithelial integrity and homogeneous ventilation during HFOV (CIC)
Other Current Grants
2014: Defining ventilation perfusion matching in the preterm lung at birth using a novel non-invasive measurement algorithm (CIA). Medical Research & Technology in Victoria Program
2014: A non-invasive, radiation-free lung imaging tool to improve intubation safety in children (CIA). Driving Business Innovation Program (Victorian Government)
2011: Curosurf award for innovation in respiratory research at the 15th Annual Congress of the Perinatal Society of Australia and New Zealand
2008: Perinatal Research Society Prize for best oral presentation at the 12th Annual Congress of the Perinatal Society of Australia and New Zealand
2006: Jean-Marie Bertrand Award for best oral presentation at 8th European conference on paediatric and neonatal ventilation, Montreux, Switzerland
2006: Award for best paediatric presentation at 31st Australian and New Zealand Annual Scientific meeting on Intensive Care
2005: Award for best paediatric presentation at 30th Australian and New Zealand Annual Scientific meeting on Intensive Care
Dr Tingay's research focuses on improving the respiratory management of infants needing intensive care and providing this vulnerable but important population every chance for a healthy start to life. His primary research involves exploring and improving how clinicians treat newborn infants and children with severe respiratory failure requiring assisted mechanical ventilation (a ventilator or 'breathing machine'). His research focuses on better understanding the physiological response to mechanical ventilation, using complex feedback and imaging tools, to develop ventilation strategies that improve lung function and prevent long-term injury. This is being achieved through a program of basic science, translational and clinical trials at the MCRI, and in collaboration with research partners in Australia and Europe.
Increasingly, neonatologists have been aware that the very first breaths of life are fundamental to a safe and effective lung function in early life and even beyond into childhood. Dr Tingay has used his unique insight into the complex physiological interactions of the diseased preterm lung and mechanical ventilation to explore better treatments that can be applied to the preterm lung from the very first breath. Using a novel and exciting lung imaging tool called Electrical Impedance Tomography, his group has developed new methods of unlocking the complex respiratory interactions at birth and beyond.
Dr Tingay's research involves a combination of clinical trials, physiological translational models, engineering, mathematical modelling and molecular science. This provides unique opportunities for researchers from many disciplines to collaborate.
- Centre of Improving Outcomes of Preterm Birth
- Optimising lung protective ventilation at birth using the volumetric response of the lung in a preterm lamb model
- Can proteomics be used to identify novel lung injury biomarkers during resuscitation strategies applied at birth in a pre-term lung?
- Inhaling medications: Aerosol delivery of vaccines to the infant lung
- Using complexity theory to model the newborn lung at birth.
Tingay DG, Wallace MJ, Bhatia R, Schmölzer GM, Zahra VA, Dolan MJ, Hooper SB, Davis PG. Surfactant before the first inflation at birth improves spatial distribution of ventilation and reduces lung injury in preterm lambs. J Appl Physiol. 2014; 116: 251-258; doi:10.1152/japplphysiol.01142.2013
Tingay DG, Bhatia R, Schmölzer GM, Wallace MJ, Zahra VA, Davis PG. Effect of sustained inflation versus step-wise PEEP strategy at birth on gas exchange and lung mechanics in preterm lambs. Pediatric Research. 2014; 75: 288-94. Doi:10.1038/pr.2013.218.
Zannin E, Ventura ML, Dellacà RL, Natile M, Tagliabue P, Perkins EJ, Bhatia R, Dargaville PA, Tingay DG. Optimal mean airway pressure during high frequency oscillatory ventilation by oxygenation, lung volumes and respiratory system reactance in preterm lambs. Pediatric Research 2013.
Tingay DG, Mills JF, Morley CJ, Pellicano A, Dargaville PA Indicators of optimal lung volume during high-frequency oscillatory ventilation in infants. Critical Care Medicine. 2013; 41 (1): 232 – 239.
Armstrong RK, Carlisle HR, Davis PG, Schibler A, Tingay DG. Distribution of tidal ventilation during volume targeted ventilation is variable and influenced by age in the preterm lung. Intensive Care Medicine. 2011; 37: 839 – 846.
Dargaville PA, Copnell B, Mills JF, Haron I, Lee JKF, Tingay DG, Rohana J, Mildenhall LF, Jeng MJ, Narayanan A, Battin MR, Kuschel CA, Sadowsky JL, Patel H, Kilburn CJ, Carlin JB, Morley CJ, for the lessMAS trial study group. Randomized controlled trial of lung lavage with dilute surfactant for meconium aspiration syndrome. Journal of Pediatrics. 2011; 158 (3): 383 – 389.
Carlisle HR, Armstrong RK, Davis PG, Schibler A, Frerichs I, Tingay DG. Regional Distribution of Blood Volume within the Preterm Infant Thorax during Synchronised Mechanical Ventilation. Intensive Care Medicine. 2010; 36 (12): 2101 – 2108.
Tingay DG, Copnell B, Grant C, Dargaville PA, Dunster K, Schibler A. The Effect Of Endotracheal Suction On Regional Tidal Ventilation And End-Expiratory Lung Volume. Intensive Care Med. 2010; 36: 888 – 896.
Pellicano A, Tingay DG, Mills JF, Fasulakis S, Morley CJ, Dargaville PA. Comparison of four methods of lung volume recruitment during high frequency oscillatory ventilation. Intensive Care Med. 2009; 35 (11): 1990.
Tingay DG, Mills JF, Morley CJ, Pellicano A, Dargaville PA. The deflation limb of the pressure-volume relationship in infants during high-frequency ventilation. Am J Respir Crit Care Med. 2006 Feb 15;173(4):414-20.