Dr Jonathan Mynard

Biography:

Dr Jonathan Mynard is the Leader of the Cardiovascular Bioengineering Team within the Heart Research group at MCRI. He is an Honorary Research Fellow with the Department of Paediatrics, University of Melbourne and Department of Cardiology, Royal Children's Hospital, and Senior Honorary Research Fellow with Department of Biomedical Engineering, University of Melbourne. Dr Mynard holds undergraduate degrees in Medical Biophysics & Intrumentation and Electrical & Electronic Engineering (Swinburne University), a Master's degree in Computer Modelling (Swansea University, Wales) and a PhD from the University of Melbourne. He completed postdoctoral research at the Biomedical Simulation Laboratory (University of Toronto, Canada). Dr Mynard is on the editorial board of Heart, Lung and Circulation and receives funding from HeartKids Australia, the National Health and Medical Research Council of Australia and the National Heart Foundation. With a background in bioengineering, his research focuses on developing and applying state-of-the-art analytical and imaging techniques to better understand and treat cardiovascular problems in infants, children and young adults. Specific areas of interests include cardiovascular modelling, fetal and neonatal cardiovascular dynamics, coronary haemodynamics, models of arterial haemodynamics, congenital heart disease, new technology for measuring blood pressure (in particular, central blood pressure) and assessment of cardiovascular risk in children and young adults.

Other Affiliations:

Honorary Research Fellow, Department of Paediatrics, University of Melbourne
Honorary Research Fellow, Department of Cardiology, Royal Children's Hospital
Senior Honorary Research Fellow, Department of Biomedical Engineering, University of Melbourne

Awards:

Artery16 Career Development Lecture (2nd Prize) "Wave potential: a unified model of arterial waves, reservoir phenomena and their interaction." 2016
CJ Martin Early Career Research Fellowship, National Health and Medical Research Council of Australia, 2011-2015
Dora Lush Biomedical Postgraduate Scholarship, National Health and Medical Research Council of Australia, 2007-2010
Ernst Hinton Memorial Prize for best Masters student in the Civil and Computational Engineering Centre, Swansea University, 2007

Research:

The focus of Dr Mynard's research is to explore new methods of assessing cardiovascular diseases before and after birth, through the use of advanced medical image analysis combined with state-of-the-art computer simulations. Dr Mynard has designed models of the heart and entire circulation of the fetus and newborn, which can be adapted to study any form of congenital heart disease.

Focus areas include:

Assessment of central blood pressure
Arterial wave analyses and haemodynamics (basic theory to bedside application)
Fetal cardiovascular dynamics
Birth transition physiology and pathophysiology
Aortic coarctation
Univentricular physiology - in particular Fontan cardiac and circulatory mechanics
Coronary haemodynamics
Image-based 3D blood flow modelling
Reduced-order (1D/0D) cardiovascular system modelling

Projects:

KidCoreBP: Central aortic blood pressure in children: establishing a gold standard non-invasive assessment of cardiovascular risk (NHMRC project grant, 2017-2019, $694,342)
Improving blood pressure measurement in children after exercise testing.
Early markers of cardiovascular risk in children and young adults.
Biomechanical factors contributing to early-onset hypertension in young adults after repair of aortic coarctation.
Image-based arterial wave analysis: translating state-of-the-art techniques
Single ventricle heart mechanics
Modelling the fetal and neonatal cardiovascular systems: normal development and congenital heart disease

(Selected list)

Rueb K, Mynard JP (equal senior author), Liu R, Wake M, Vuillermin P, Ponsonby A-L, Zannino D, Burgner D. “Changes in Carotid Artery Intima-Media Thickness during the Cardiac Cycle: A Comparative Study in Early Childhood, Mid-Childhood and Adulthood”, VASA – European Journal of Vascular Medicine, In Press, Accepted 21/2/2017

Mynard JP, Kowalski R, Cheung MMH, Smolich JJ. “Beyond the aorta: Partial transmission of reflected waves from aortic coarctation into supra-aortic branches modulates cerebral hemodynamics and left ventricular load,” Biomechanics and Modelling in Mechanobiology, 16(2):635-650, 2017.

Mynard JP, Smolich JJ. "Influence of anatomical dominance and hypertension on coronary conduit arterial and microcirculatory flow patterns: a multi-scale modeling study." American Journal of Physiology - Heart & Circulatory Physiology, 311(1):H11-H23, 2016

Smolich JJ, Mynard JP. “Major contribution of central pulmonary reservoir discharge to increased pulmonary arterial diastolic blood flow after birth in near-term lambs”, American Journal of Physiology - Regulatory Integrative & Comparative Physiology, 311(4):R702-R709, 2016

Mynard JP, Smolich JJ. “Novel wave power analysis linking pressure-flow waves, wave potential and the forward and backward components of hydraulic power”, American Journal of Physiology – Heart & Circulatory Physiology, 310(8):H1026-H1038, 2016

Smolich JJ, Kenna K, Mynard JP. “Retrograde lower body arterial reservoir discharge underlies rapid reversal of ductus arteriosus shunting after early cord clamping at birth in preterm lambs”, Journal of Applied Physiology, 120(4):399-407, 2016

Mynard JP, Valen-Sendstad, “A unified method for estimating pressure losses at vascular junctions”, International Journal for Numerical Methods in Biomedical Engineering, 31(7):e02717, 2015

Mynard JP, Smolich JJ. “One-dimensional haemodynamic modelling and wave dynamics in the entire adult circulation”, Annals of Biomedical Engineering, 43(6):1443-60, 2015

Mitha AP, Mynard JP (equal first author), Storwick JA, Shivji ZI, Wong JH, Morrish W. “Can the Windkessel Hypothesis Explain Delayed Intraparenchymal Haemorrhage After Flow Diversion? A Case Report and Model-Based Analysis of Possible Mechanisms”, Heart, Lung and Circulation, 24(8):824-30, 2015

Mynard JP, Smolich JJ. “Wave potential and the one-dimensional windkessel as a wave-based paradigm of diastolic arterial hemodynamics”, American Journal of Physiology – Heart & Circulatory Physiology, 307(3):H307-H318, 2014

Mynard JP, Penny DJ, Smolich JJ. “Scalability and in-vivo validation of a multi-scale numerical model of the left coronary circulation", American Journal of Physiology – Heart & Circulatory Physiology, 306(4):H517–H528, 2014

Mynard JP, Wasserman BA, Steinman DA. "Errors in the estimation of wall shear stress by maximum Doppler velocity", Atherosclerosis, 227(2):259-66, 2013

Mynard JP, Steinman DA. "Effect of velocity profile skewing on blood velocity and volume flow waveforms derived from maximum Doppler spectral velocity", Ultrasound in Medicine & Biology, 39(5):870-81, 2013

Mynard JP, Davidson MR, Penny DJ, Smolich JJ. “Non-linear separation of pressure, velocity and wave intensity into forward and backward components", Medical & Biological Engineering & Computing, 50(6):641-648, 2012

Mynard JP, Penny DJ, Davidson MR, Smolich JJ. “The reservoir-wave paradigm introduces error into arterial wave analysis: a computer modelling and in vivo study", Journal of Hypertension, 30(4):734-743, 2012

Mynard JP, Davidson MR, Penny DJ, Smolich JJ. “A simple, versatile valve model for use in lumped parameter and one-dimensional cardiovascular models", International Journal for Numerical Methods in Biomedical Engineering, 28(6-7):626-41, 2012

Smolich JJ, Mynard JP, Penny DJ. “Pulmonary trunk, ductus arteriosus and pulmonary arterial phasic blood flow interactions during systole and diastole in the fetus", Journal of Applied Physiology, 110(5):1362-1373, 2011

Mynard JP, Davidson M, Penny DJ and Smolich JJ. “A numerical model of neonatal pulmonary atresia with intact ventricular septum and RV-dependent coronary flow," International Journal for Numerical Methods in Biomedical Engineering, 26(7):843-861, 2010

Smolich JJ, Mynard JP, Penny DJ. “Ductus arteriosus wave intensity analysis in fetal lambs: mid-systolic ductal flow augmentation is due to antegrade pulmonary arterial wave transmission", American Journal of Physiology – Regulatory Integrative & Comparative Physiology, 297(4):R1171-1179, 2009 (Impact Factor: 3.661)

Funding: