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Dr Lien Anh Ha Do
Dr Do obtained a PhD in BioMedical Sciences through a program between the Oxford University Clinical Research Unit (OUCRU), Vietnam, Genome Institute of Singapore, Singapore and Open University, the United Kingdom in 2013. Her PhD project focused on human respiratory syncytial virus (RSV) infections in infants and small children in Viet Nam and encompassed (molecular) epidemiological, clinical, virological and host expression profile studies. In addition, she graduated as a medical doctor (M.D) in Vietnam in 2001. She had training programs with Pasteur Institute in Paris, France and Virology laboratory at University Hospital Pellegrin, Bordeaux, France (2002-2005) and worked at Clinical Pathology laboratories in Vietnam and in Queensland, Australia prior to joining MCRI.
As a medical doctor and a scientist, she has been involved in designing, implementing different clinical study protocols as well as in coordinating/ managing clinical studies on respiratory viruses. She is leading projects in Vietnam, Mongolia and Australia. These projects aim to understand the pathogenesis and molecular characteristics of RSV, how these factors impact on clinical outcomes and health economics, and how these findings can be translated into improved clinical management and prevention of RSV, particularly in low-middle income countries settings.
Dr Do has supervised 3 Honours student and is currently supervising a Masters student and a PhD student.
Honorary Fellow, Department of Paediatrics, The University of Melbourne, Australia.
2019: Travel grant from Revisnet meeting
2018: Travel grant from 11th International Respiratory Syncytial Virus Symposium, Asheville, North Carolina, USA
2016: Travel grant from RSV 16 Symposium at Bariloche, Argentina
2010-2013: PhD grant from Wellcome Trust Major Overseas Program
2003-2005: Full scholarship for Masters of Biomedical Science on Microbiology and Immunology, from Embassy of France in Viet Nam and Association of French-speaking universities
2002: Full scholarship "Allocations pour mobilité de stage professionnel" from Association of French-speaking universities for professional training in France.
Dr Do is particularly interested in exploring the host susceptibility to severe RSV infection as well as the molecular characteristic of the virus in order to identify biomarkers and viral factors that predict the disease outcome. The two projects conducted in Ho Chi Minh City, Vietnam and in Melbourne, Australia are aiming to answer this question. In collaborations with A/Prof Licciardi and A/Prof Pellicci, the host immune responses to RSV infection between preterm and term infants in Vietnam using high-throughput immunological platforms are under investigation. Together with Dr Danielle Wurzel, a clinical dataset has been built to identify clinical risk factors of severe RSV infections among children vising the Royal Children Hospital, Australia.
Research into RSV pathogenesis and development of novel vaccines is rapidly evolving with a high number of vaccines or monoclonal antibodies (mAb) at phase 2, one already finished in phase 3 (Resvax, Novavax) and one long-active mAb (Nirsevimab, AstraZeneca) in on-going phase 3. With a clinical and virological background and under Prof Kim Mulholland's guidance, Dr Do's research focuses to build up an RSV research capacity, clinical sites and research networks in Australia, Mongolia and Vietnam; all these activities are important preparation steps for future RSV vaccine trials.
Dr Do's is also interested in exploring potential uses of available therapeutics and vaccines, such as palivizumab and measles vaccine, to treat or prevent (severe) RSV infections.
In addition, Dr Do's research also participates in the effort to evaluate the health economic burden of RSV disease in low-middle income countries settings.
Impact of Pneumococcal Conjugate Vaccine on RSV and Influenza Infections in Mongolia
Immune Response to Respiratory Syncytial Virus in Cord Blood from Preterm and Term Infants
Estimating the economic burden of acute respiratory illness in infants in Vietnam: a cohort study
In vitro trained immunity effect of measles vaccine
Molecular epidemiology of severe respiratory syncytial virus infections in children under 2 years of age in Australia
Do LAH, Anderson J, Sutton P, Pellicci DG, Mulholland K, Licciardi PV. Understanding COVID-19 in children may provide clues to protect at-risk populations. BMJ Paediatr Open. 2020 May 14;4(1):e000702. doi:10.1136/bmjpo-2020-000702.
Rajapaksa AE, Do LAH, Ong DS, Sourial M, Veysey D, Beare R et al. Pulmonary deposition of radionucleotide-labeled palivizumab: proof-of-concept study Frontiers in Pharmacology 11, 1291(in press).
Anderson J, Do LAH, Toh ZQ, Hoe E, Reitsma A, Mulholland K, Licciardi PV. Vitamin D Induces Differential Effects on Inflammatory Responses During Bacterial and/or Viral Stimulation of Human Peripheral Blood Mononuclear Cells. Front Immunol. 2020 Apr 7;11:602. doi: 10.3389/fimmu.2020.00602.
Do LAH, Tsedenbal N, von Mollendorf C, Mungun T, Bardach D, Mulholland K. What was the real cause of the dramatic increase in measles mortality during the 2015/2016 Mongolian Outbreak? J Infect Dis. 2020 Feb 27:jiaa084. doi: 10.1093/infdis/jiaa084. Epub ahead of print.
Toh ZQ, Kosasih J, Russell FM, Reyburn R, Fong J, Tuivaga E, Ratu FT, Nguyen CD, Matanitobua S, Do LAH, Menheniott T, Frazer IH, Garland SM, Mulholland EK, Licciardi PV. Selective Persistence of HPV Cross-Neutralising Antibodies following Reduced-Dose HPV Vaccine Schedules. Vaccines (Basel). 2019 Nov 28;7(4):200. doi: 10.3390/vaccines7040200.
Li Y, Reeves RM, Wang X, Bassat Q, Brooks WA, Cohen C, .. Do LAH...et al. Global patterns in monthly activity of influenza virus, respiratory syncytial virus, parainfluenza virus, and metapneumovirus: a systematic analysis. Lancet Glob Health. 2019;7(8):e1031-e45. doi: 10.1016/S2214-109X(19)30264-5.
La Vincente SF, von Mollendorf C, Ulziibayar M, Satzke C, Dashtseren L, Fox KK, Dunne EM, Nguyen CD, de Campo J, de Campo M, Thomson H, Surenkhand G, Demberelsuren S, Bujinlkham S, Do LAH, Narangerel D, Cherian T, Mungun T, Mulholland EK. Evaluation of a phased pneumococcal conjugate vaccine introduction in Mongolia using enhanced pneumonia surveillance and community carriage surveys: a study protocol for a prospective observational study and lessons learned. BMC Public Health. 2019 Mar 21;19(1):333. doi: 10.1186/s12889-019-6639-y.
Do LAH, Tse R, Nathanielsz J, Anderson J, Ong DS, Chappell K, Mulholland K, Licciardi PV. An Improved and High Throughput Respiratory Syncytial Virus (RSV) Micro-neutralization Assay. J Vis Exp. 2019 Jan 26;(143). doi: 10.3791/59025.
Anderson J, Toh ZQ, Reitsma A, Do LAH, Nathanielsz J, Licciardi PV. Effect of peripheral blood mononuclear cell cryopreservation on innate and adaptive immune responses. J Immunol Methods. 2019 Feb;465:61-66. doi: 10.1016/j.jim.2018.11.006. Epub 2018 Nov 14.
Do LAH, Mulholland K. How long are children protected by influenza vaccination? Lancet Respir Med. 2018 Dec;6(12):889-891. doi:10.1016/S2213-2600(18)30463-6. Epub 2018 Nov 12.
Linster M, Do LAH, Minh NNQ, Chen Y, Zhe Z, Tuan TA, Tuan HM, Su YCF, van Doorn HR, Moorthy M, Smith GJD. Clinical and Molecular Epidemiology of Human Parainfluenza Viruses 1-4 in Children from Viet Nam. Sci Rep. 2018 May 1;8(1):6833. doi: 10.1038/s41598-018-24767-4.
B'Krong NTTC, Minh NNQ, Qui PT, Chau TTH, Nghia HDT, Do LAH, Nhung NN, Van Vinh Chau N, Thwaites G, Van Tan L, van Doorn HR, Thanh TT. Enterovirus serotypes in patients with central nervous system and respiratory infections in Viet Nam 1997-2010. Virol J. 2018 Apr 12;15(1):69. doi: 10.1186/s12985-018-0980-0.
Do LAH, Pellet J, van Doorn HR, Tran AT, Nguyen BH, Tran TTL, Tran QH, Vo QB, Tran Dac NA, Trinh HN, Nguyen TTH, Le Binh BT, Nguyen HMK, Nguyen MT, Thai QT, Vo TV, Ngo NQM, Dang TKH, Cao NH, Tran TV, Ho LV, De Meulder B, Auffray C, Hofstra JJ, Farrar J, Bryant JE, de Jong M, Hibberd ML. Host Transcription Profile in Nasal Epithelium and Whole Blood of Hospitalized Children Under 2 Years of Age With Respiratory Syncytial Virus Infection. J Infect Dis. 2017 Dec 27;217(1):134-146. doi: 10.1093/infdis/jix519.
Ny NTH, Anh NT, Hang VTT, Nguyet LA, Thanh TT, Ha DQ, Minh NNQ, Do LAH et al. Enterovirus D68 in Viet Nam (2009-2015). Wellcome Open Res. 2017;2:41. doi: 10.12688/wellcomeopenres.11558.2.
Do LAH, Bryant JE, Tran AT, Nguyen BH, Tran TT, Tran QH, Vo QB, Tran Dac NA, Trinh HN, Nguyen TT, Le Binh BT, Le K, Nguyen MT, Thai QT, Vo TV, Ngo NQ, Dang TK, Cao NH, Tran TV, Ho LV, Farrar J, de Jong M, van Doorn HR. Respiratory Syncytial Virus and Other Viral Infections among Children under Two Years Old in Southern Vietnam 2009-2010: Clinical Characteristics and Disease Severity. PLoS One. 2016 Aug 8;11(8):e0160606. doi: 10.1371/journal.pone.0160606.
Do LAH, Wilm A, van Doorn HR, Lam HM, Sim S, Sukumaran R, Tran AT, Nguyen BH, Tran TTL, Tran QH, Vo QB, Dac NAT, Trinh HN, Nguyen TTH, Binh BTL, Le K, Nguyen MT, Thai QT, Vo TV, Ngo NQM, Dang TKH, Cao NH, Tran TV, Ho LV, Farrar J, de Jong M, Chen S, Nagarajan N, Bryant JE, Hibberd ML. Direct whole-genome deep- sequencing of human respiratory syncytial virus A and B from Vietnamese children identifies distinct patterns of inter- and intra-host evolution. J Gen Virol. 2015 Dec;96(12):3470-3483. doi: 10.1099/jgv.0.000298.
Tuan TA, Thanh TT, Hai Nt, Tinh le BB, Kim le TN, Do LAH, Chinh B'Krong Nt, Tham NT, Hang Vt, Merson L, Farrar J, Thuong TC, de Jong MD, Schultsz C, van Doorn HR. Characterization of hospital and community-acquired respiratory syncytial virus in children with severe lower respiratory tract infections in Ho Chi Minh City, Vietnam, 2010. Influenza Other Respir Viruses. 2015 May;9(3):110-9. doi: 10.1111/irv.12307.
Lee LY, Ha do LA, Simmons C, et al. Memory T cells established by seasonal human influenza A infection cross-react with avian influenza A (H5N1) in healthy individuals [published correction appears in J Clin Invest. 2012 Nov 1;122(11):4301]. J Clin Invest. 2008;118(10):3478-3490. doi:10.1172/JCI32460.
Do LAH, van Doorn HR, Bryant JE, Nghiem MN, Nguyen Van VC, Vo CK, Nguyen MD, Tran TH, Farrar J, de Jong MD. A sensitive real-time PCR for detection and subgrouping of human respiratory syncytial virus. J Virol Methods. 2012 Jan;179(1):250-5. doi: 10.1016/j.jviromet.2011.11.012. Epub 2011 Nov 19.
Do AH, van Doorn HR, Nghiem MN, et al. Viral etiologies of acute respiratory infections among hospitalized Vietnamese children in Ho Chi Minh City, 2004-2008. PLoS One. 2011;6(3):e18176. Published 2011 Mar 24. doi:10.1371/journal.pone.0018176
- Bill and Melinda Gates Foundation
- PATH, USA
- Theme grant