Prof Paul Lockhart
Prof Paul Lockhart
Details
Role
Group Leader / Co-Director BLC
Research area
Bruce Lefroy Centre
Group
Neurogenetics (BLC)
Professor Paul Lockhart is the Group Leader of Neurogenetic research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute (MCRI)
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, to establish a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.
Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded an NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 41 causal and >500 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, to establish a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.
Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded an NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 41 causal and >500 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Professor Paul Lockhart is the Group Leader of Neurogenetic research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute (MCRI)
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in...
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in...
Professor Paul Lockhart is the Group Leader of Neurogenetic research and Co-Director of the Bruce Lefroy Centre at the Murdoch Children's Research Institute (MCRI)
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, to establish a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.
Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded an NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 41 causal and >500 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Paul received his PhD in Genetics (Title: Molecular analysis of copper transport in sheep) from the University of Melbourne in 2000. He was awarded a NHMRC CJ Martin Fellowship to study the genetics of neurodegenerative disorders, specifically Parkinson's disease, with Professor John Hardy (2000-2001) and Professor Matthew Farrer (2002-2003) at The Mayo Clinic, Florida. He returned to Australia in 2004 and joined the newly formed Bruce Lefroy Centre (BLC) at Murdoch Children's Research Institute, to establish a laboratory research group to complement the clinical and public health research activities of the BLC. He received a NHMRC RD Wright Fellowship in 2005 and was appointed Co-Director of the BLC in 2009.
Paul initiated a new research direction in 2009, utilising new sequencing technologies to identify genes causing neurogenetic disorders and was awarded an NHMRC CDA2 Fellowship in 2012 and Vincent Chiodo Foundation Fellowship in 2019. His research has identified 41 causal and >500 risk genes for genetic disorders in the last decade, delineating new pathways to disease and translating these research findings to improved diagnostics, treatment and prevention of disease.
Top Publications
- Kantor, I, Wright, JL, Amor, DJ, Lockhart, PJ. Generation of two tetracycline-inducible NGN2 iN iPSC lines carrying a heterozygous floating-Harbor syndrome SRCAP truncating mutation.. Stem Cell Res 91: 103922 2026 view publication
- Bozaoglu, K, Massie, S, Irion, FE, Davies, KC, Kantor, I, Raabus, M, Haebich, KM, Vlahos, K, Howden, SE, Wright, J, et al. Simultaneous reprogramming and gene correction to generate six iPSC lines and isogenic controls from individuals with neurofibromatosis type 1.. Stem Cell Res 90: 103904 2026 view publication
- Syriani, DA, Wong, D, De Gusmao, CM, Andani, S, Mao, Y, Glotzer, G, Lockhart, PJ, Hassin-Baer, S, Khurana, V, Das, S, et al. Prevalence of RFC1-Mediated Spinocerebellar Ataxia in a United States Ataxia Cohort. 790006 2026 view publication
- Trevis, KJ, Brown, NJ, Green, C, Lockhart, P, Hickey, P, Fanjul-Fernández, M, Bromhead, C, Desai, T, Vick, T, Gillies, G, et al. Tracing Autism Traits in Large Multiplex Families to Identify Endophenotypes of the Broader Autism Phenotype. 659722 2026 view publication
- Stephenson, SE, Owens, HG, Richards, KL, Lee, WS, D’Arcy, C, Barton, S, Mandelstam, SA, Maixner, WJ, MacGregor, D, Petrou, S, et al. Dysmorphic neuron density underlies intrinsic epileptogenicity of the centre of cortical tubers. 621607 2026 view publication
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