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Professor Julie Bines
Professor Julie Bines is the inaugural Victor and Loti Smorgon Professor of Paediatrics and Deputy Head of Department of Paediatrics at the University of Melbourne.
Professor Bines is a Paediatric Gastroenterologist at The Royal Children's Hospital in Melbourne where she leads the Clinical Nutrition Program. This program is a national referral centre for children with complex nutritional problems and intestinal failure and is linked with the Australian Paediatric Intestinal Transplantation Program. At the Murdoch Childrens Research Institute, Professor Bines leads the RV3 Rotavirus Vaccine Program which aims to develop a low-cost vaccine to prevent rotavirus disease from birth.
Professor Bines graduated as an M.B.B.S. (Bachelor Medicine, Bachelor Surgery) from Monash University in 1982 and obtained her Doctorate of Medicine (MD) from the University of Melbourne in 1990. She trained in Paediatric Gastroenterology and Nutrition at Children's Hospital, Massachusetts General Hospital and Harvard Medical School, Boston (1988-91) and was a Postdoctoral Fellow at Massaschusetts Institute of Technology (1989-91).
Group leader, Intestinal Failure and Clinical Nutrition, Infection and Immunity Theme, Murdoch Childrens Research Institute
- NHMRC Practitioner Fellowship
- Fellow, American Gastroenterology Association
- Faculty, European Society for Parenteral and Enteral Nutrition
- Victorian Public Healthcare Innovation Award
- Part-time Career Development Award, Murdoch Childrens Research Institute
- Bob McMahon Research Award, Australian Society for Parenteral and Enteral Nutrition
- David Russell Clinical Research Award, Australian Society for Parenteral and Enteral Nutrition
- Charles A. Janeway Fellowship Award, The Children's Hospital, Boston
- Henry and Rachel Ackerman Scholarship, The University of Melbourne
- Jenny Poolman Travelling Scholarship, The Royal Children's Hospital, Melbourne
Professor Julie Bines leads the RV3 Rotavirus Vaccine Program at the Murdoch Childrens Research Institute, a program which aims to develop a low-cost neonatal rotavirus vaccine to prevent rotavirus disease from birth. This program builds on 40 years of internationally recognised contribution to the understanding of rotavirus infection and the development of rotavirus vaccines. Professor Bines has also been involved in activities related to post-marketing surveillance of rotavirus vaccines, particularly with respect to intussusception. She led the development of the Brighton Collaboration clinical case definition for intussusception and the WHO generic protocol for post-marketing surveillance of the safety of rotavirus vaccines.
Professor Bines also leads the Intestinal Failure and Clinical Nutrition Research Group at the Murdoch Childrens Research Institute. This group focuses on applied clinical research using a preclinical model of short bowel syndrome in children using the juvenile piglet model. The focus of this research includes the pathogenesis of intestinal failure associated with liver disease, changes in the microbiome and metabolome in short bowel syndrome and intestinal adaptation following massive small bowel resection.
- Phase 2 trial of the immunogenicity and efficacy of the RV3-BB rotavirus vaccine (Indonesia)
- Phase 2 trial of the safety and immunogenicity of the RV3-BB rotavirus vaccine (New Zealand)
- Development of the RV3-BB rotavirus vaccine
- Pathogenesis of intestinal failure associated liver disease in children with short bowel syndrome
PEREIRA-FANTINI P, LAPTHORNE S, JOYCE SA, DELLIOS N, WILSON G, FOUHY F, THOMAS SL, SCURR M, HILL C, GAHAN CG, COTTER PD, FULLER PJ, HARDIKAR W, BINES JE
Altered FXR signalling is associated with bile acid dysmetabolism in short bowel syndrome-associated liver disease.
Journal of Hepatology, 2014 (in press)
RID A, SAXENA A, ABDHULLAH HB, BHAN A, BINES J, BOUESSEAU MC, CAPLAN A, COLGROVE J, DHAI A, GOMEZ-DIAZ R, GREEN SK, KANG G, LAGOS R, LOH P, LONDON AJ, MULHOLLAND K, NEELS P, PITISUTTITHUM P, SARR SC, SELGELID M, SHEEHAN M, SMITH PG
Placebo use in vaccine trials: Recommendations of a WHO expert panel.
Vaccine 2014: dx.doi.org/10.1016/j.vaccine.2014.04.022
JIANG J, JIANG B, PARASHAR U, NGUYEN T, BINES J, PATEL MM
Childhood Intussusception: A Literature Review
Plos One 2013; 8(7): e68482
LAPTHORNE S, PEREIRA-FANTINI PM, FOUHY F, WILSON G, THOMAS SL, DELLIOS NL, SCURR M, O'SULLIVAN O, ROSS RP, STANTON C, FITZGERALD GF, COTTER PD, BINES JE
Gut microbial diversity is reduced and is associated with colonic inflammation in a piglet model of short bowel syndrome.
Gut Microbes 2013; 4(3): pp 212-21
BINES JE, JAMIESON P
Designing new collaborative learning spaces in clinical environments: experiences from a children's hospital in Australia.
Journal of Interprofessional Care 2013; 27(S2); pp63-68
DANCHIN M, KIRKWOOD CD, LEE KJ, BISHOP RF, WATTS E, JUSTICE FA, CLIFFORD V, COWLEY D, BUTTERY JP, BINES JE
Phase I trial of RV3-BB rotavirus vaccine: A human neonatal rotavirus vaccine.
Vaccine 2013; 31(23): pp 2610-16
CARLIN JB, MACARTNEY KK, LEE KJ, QUINN HE, BUTTERY J, BINES J, MCINTYRE PB
Intussusception Risk and Disease Prevention Associated with Rotavirus Vaccines in Australia's National Immunization Program.
Clinical Infectious Diseases 2013; 57(10): pp1427-34
TATE JE, STEELE AD, BINES JE, ZUBER PLF, PARASHAR U
Research priorities regarding rotavirus vaccine and intussusceptions: A meeting summary.
Vaccine 2012; 30(Suppl 1): p A179-84
DANCHIN M, BINES JE
Defeating Rotavirus? The Global Recommendation for Rotavirus Vaccination. [Perspective]
New England Journal of Medicine 2009; 361(20):1919-21
BINES JE, PATEL M, PARASHAR U
Assessment of post-licensure safety of rotavirus vaccines, with emphasis on intussusception.
Journal of Infectious Diseases 2009; 200(Suppl 1):S282-90