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Professor Nigel Curtis
Professor Nigel Curtis is a clinician scientist. He is the leader of the Infectious Diseases & Microbiology Research Group at the Murdoch Childrens Research Institute, Professor of Paediatric Infectious Diseases at the University of Melbourne and Head of Infectious Diseases at The Royal Children's Hospital Melbourne.
Professor Curtis did his preclinical training at the University of Cambridge and clinical training at St Mary's Medical School, University of London. He completed specialist training in pediatric infectious diseases with Fellowships in both London and Vancouver. He has also worked for short periods in The Gambia, Zimbabwe and South Africa. Professor Curtis undertook his laboratory training at Imperial College London St Mary's Campus, where he completed a PhD investigating the role of bacterial superantigen toxins in Kawasaki disease and in staphylococcal and streptococcal toxic shock sydrome.
Professor Curtis' clinical and laboratory research focuses on improving the diagnosis, treatment and prevention of infectious diseases in children. His laboratory uses the latest immunological and molecular techniques to investigate the host immune response. He has supervised 16 PhD, two BSc Honours, five BMedSci, seven AMS and two SS students. He has also supervised more than 40 RACP projects.
In addition to his clinical and research roles, Professor Curtis has a strong interest in graduate student training. He is Chair of the Department of Paediatrics Graduate Research Committee and a member of the University of Melbourne Research Higher Degree Committee and Faculty Research Training Committee.
- Professor of Paediatric Infectious Diseases, Department of Paediatrics, The University of Melbourne
- Head of Infectious Diseases, The Royal Children's Hospital Melbourne
Professor Curtis has a wide range of clinical and laboratory research interests.
His clinical research encompasses clinical trials, observational studies and systematic reviews of a wide variety of childhood infectious diseases, including bacterial meningitis, infections in the immunocompromised, and Kawasaki disease. He is also a staunch advocate of appropriate antimicrobial use and is involved in antibiotic stewardship and a randomised controlled trial of neonatal vancomycin dosing.
His laboratory research has a particular focus on host-pathogen interactions and the immune response to infections. He has led studies on the role of superantigens in the aetiology of Kawasaki disease, and the pathogenesis of severe staphylococcal and streptococcal disease, including acute rheumatic fever. Current research projects focus on the immune response to BCG vaccine and the immunodiagnosis of childhood tuberculosis. Professor Curtis is currently leading a large randomised controlled trial of BCG immunisation of infants in Melbourne to investigate the immunomodulatory ('non-specific') effects of this vaccine, including its ability to prevent infections and allergic disease. Find our more at: http://misbair.org.au/
- Immunodiagnosis of childhood tuberculosis (TB)
- The Melbourne Infant Study: BCG for Allergy and Infection Reduction (MIS BAIR)
- Immunological and molecular studies investigating the heterologous effects of BCG vaccine
- Clinical infectious diseases projects
Heterologous ("nonspecific") and sex-differential effects of vaccines: epidemiology, clinical trials, and emerging immunologic mechanisms. Flanagan KL, van Crevel R, Curtis N, Shann F, Levy O; Optimmunize Network. Clin Infect Dis. 2013 Jul;57(2):283-9. doi: 10.1093/cid/cit209. Epub 2013 Apr 9. Review. PMID: 23572484
Non-specific effect of Bacille Calmette-Guérin vaccine on the immune response to routine immunisations. Ritz N, Mui M, Balloch A, Curtis N. Vaccine. 2013 Jun 26;31(30):3098-103. doi: 10.1016/j.vaccine.2013.03.059. Epub 2013 Apr 10. PMID: 23583897
The contribution of non-conventional T cells and NK cells in the mycobacterial-specific IFN? response in Bacille Calmette-Guérin (BCG)-immunized infants. Zufferey C, Germano S, Dutta B, Ritz N, Curtis N. PLoS One. 2013 Oct 3;8(10):e77334. doi: 10.1371/journal.pone.0077334. eCollection 2013. PMID: 24098583
The influence of bacille Calmette-Guerin vaccine strain on the immune response against tuberculosis: a randomized trial. Ritz N, Dutta B, Donath S, Casalaz D, Connell TG, Tebruegge M, Robins-Browne R, Hanekom WA, Britton WJ, Curtis N. Am J Respir Crit Care Med. 2012 Jan 15;185(2):213-22. doi: 10.1164/rccm.201104-0714OC. Epub 2011 Nov 3. PMID: 22071384
A comparative analysis of polyfunctional T cells and secreted cytokines induced by Bacille Calmette-Guérin immunisation in children and adults. Ritz N, Strach M, Yau C, Dutta B, Tebruegge M, Connell TG, Hanekom WA, Britton WJ, Robins-Browne R, Curtis N. PLoS One. 2012;7(7):e37535. doi: 10.1371/journal.pone.0037535. Epub 2012 Jul 19. PMID: 22829867
- National Health and Medical Research Council
- The John Burge Trust