SAEFVIC (Surveillance of Adverse Events Following Vaccination In the Community) is a public health partnership initiative of the Victorian Immunisation Program funded by the Department of Health, Victoria. It was established in 2007 and now comprises of two units at two sites:
- Clinical - Murdoch Childrens Research Institute.
- Epidemiology and Signal Investigation - Monash Health & University
SAEFVIC is a vaccine safety service and clinical immunisation research team, focusing on vaccine safety and surveillance. This includes management of adverse events following immunisation (AEFI), vaccine-preventable disease research and immunisation education.
SAEFVIC is a national leader in vaccine safety. The team comprises of immunisation nurses, administrative staff, research staff, an epidemiologist, statistician, data manager and clinicians. It is a specialist vaccine safety service that helps immunisation providers report and manage both children and adults who have had an AEFI. Our Outpatient clinics are based at The Royal Children's Hospital (Parkville) and Monash Health (Clayton). SAEFVIC also provides regional clinical support via TeleHealth. Any trends in reports are notified and investigated quickly in close liaison with Victorian and national health authorities, such as the Therapeutic Goods Adminsitration
SAEFVIC clinical research includes surveillance and clinical studies. Surveillance projects incorporate active and passive studies, including involvement in national collaborative networks, such as the AusVaxSafety and PAEDS (Paediatric Active Enhanced Surveillance) networks. These networks focus on conditions of public health importance and support the National Immunisation Program.
We also have National Health and Medical Research Centre (NHMRC)-funded projects, such as vaccine safety research into febrile seizures. SAEFVIC’s education activities include the Melbourne Vaccine Education Centre.
The Melbourne Vaccine Education Centre (MVEC)
MVEC was launched in February 2014 as a collaboration between the Melbourne Children’s campus and Monash Health. It is a web based initiative, providing up to date immunisation information for healthcare professionals, parents and the public. It aims to address common queries around vaccines and to promote the benefits of immunisation for both children and adults. It provides an A-Z list of immunisation references as well as an up to date schedule app for smart phones. MVEC runs annual education programs such as the Clinical Vaccinology Update and the Travel Vaccinology Update. Click on header to proceed to the MVEC website.
AusVaxSafety is a national, Commonwealth Department of Health funded, enhanced surveillance system to monitor adverse events following various immunisations (presently pertussis and influenza vaccinations are being monitored). The MCRI AusVaxSafety team uses a data extraction tool called Vaxtracker. After consenting to participation, parents receive an SMS text message three-days following routine vaccination asking if their child had experienced any kind of reaction post vaccination. Reactions are then followed up appropriately as per Victoria’s protocol for adverse events following immunisation. Each week, data from all reports are combined and analysed. Surveillance under AusVaxSafety commenced in March 2014 and up-to-date results on this important vaccine safety initiative are detailed on the website. Click on header to proceed to the AusVaxSafety website.
AEFI-CAN (Adverse event following immunisation- clinical assessment network)
AEFI-CAN is a Commonwealth Department of Health funded, national clinical assessment network coordinated by SAEFVIC. It is a formal collaboration between state-based vaccine safety clinics, participating paediatric clinicians and the Therapeutics Goods Administration (TGA). It was initiated to help improve and develop consistency in the approach to surveillance of, and clinical responses to, adverse events following immunisation. The pilot focused on the introduction of the Human Papillomavirus (HPV) vaccine and adverse events following this launch. In 2016 AEFI-CAN expanded to cover all National Immunisation Program vaccines and all other approved vaccines.
PAEDS (Paediatric Active Enhanced Disease Surveillance)
Is a national collaboration using hospital-based active surveillance to identify and investigate serious childhood conditions of public health importance, particularly vaccine-preventable diseases and adverse events following immunisations. The aims of PAEDS are:
- To actively collect detailed information that isn’t available from other surveillance systems, about children hospitalised with serious childhood conditions of public health importance
- To inform vaccination policy and practice, including vaccine safety
- To improve child health outcomes.
PAEDS is funded by the Australian Government Department of Health with contributions from the state health departments. Funding from external sources such as NHMRC grants, also supplement certain surveillance activities.
Conditions of interest include:
- Acute Flaccid Paralysis
- Acute Childhood Encephalitis
- Varicella and Herpes Zoster
- Invasive Group A Streptococcus
- Invasive Meningococcal Disease
Further information can be found at www.paeds.edu.au
Febrile Seizures Following vaccination in children: What is the long term clinical and developmental outcome?
This is multi-centre NHMRC funded project conducted at Murdoch Childrens and The Royal Children's Hospital; The Epilepsy Research Centre, VIC; The Children’s Hospital at Westmead, NSW; Women’s and Children’s Hospital, SA; Princess Margaret Hospital, WA.
This study aims to i) determine the clinical and developmental outcome of children who had a FS when they were aged 2 years or younger and ii) look for specific genetic markers that may be linked to why the child had a FS.
TestOv Pneumo (Evaluation of the effectiveness of the 13-Valent Pneumococcal Conjugate vaccine against pneumococcal pneumonia in children)
TestOv Pneumo is a national, multi-site, NHMRC funded, prospective case control study to evaluate the efficacy of the 13-valent pneumococcal conjugate vaccine against pneumococcal pneumonia. The aims of the study are:
- To evaluate the effectiveness of the 13-valent pneumococcal conjugate vaccine (introduced to NIP in 2011) for preventing hospitalisation for streptococcal pneumonia (SP) and all cause pneumonia.
- To investigate SP non-vaccine serotype replacement
- To determine the contribution of SP to complicated & uncomplicated pneumonia
- Influenza vaccination: Uptake and associations in a cross-sectional study of children with special risk medical conditions. 2018
- Recurrence risk of a hypotonic hyporesponsive episode in two Australian specialist immunisation clinics. 2018
- Respiratory virus detection and co-infection in children and adults in a large Australian hospital in 2009-2015. 2018
- Splenic cyst and its management in a 21-month-old boy: a rare complication of invasive meningococcal disease. 2018
- Vaccine Update: Recent Progress With Novel Vaccines, and New Approaches to Safety Monitoring and Vaccine Shortage. 2018
- Adverse events following vaccination of older people may be under-reported. 2017
- Allergic adverse events following 2015 seasonal influenza vaccine, Victoria, Australia. 2017
- An increase in accident and emergency presentations for adverse events following immunisation after introduction of the group B meningococcal vaccine: an observational study. 2017
- Association Between Prenatal Alcohol Exposure and Craniofacial Shape of Children at 12 Months of Age. 2017
- Bradycardia and Hypothermia Complicating Azithromycin Treatment. 2017
- Evaluation of 'SAEFVIC', A Pharmacovigilance Surveillance Scheme for the Spontaneous Reporting of Adverse Events Following Immunisation in Victoria, Australia. 2017
- External Validation of Six Pediatric Fever and Neutropenia Clinical Decision Rules. 2017
- Failure to thrive: Case definition & guidelines for data collection, analysis, and presentation of maternal immunisation safety data. 2017
- Influenza-associated Encephalitis/Encephalopathy Identified by the Australian Childhood Encephalitis Study 2013-2015. 2017
- Kawasaki disease and immunisation: A systematic review. 2017
- The Spectrum and Burden of Influenza-Associated Neurological Disease in Children: Combined Encephalitis and Influenza Sentinel Site Surveillance from Australia 2013-2015. 2017
- Antenatal pertussis vaccination: Are we implementing best evidence into practice? 2016
- Don't aim too high: Avoiding shoulder injury related to vaccine administration. 2016
- Interesting microorganism. 2016
- Kawasaki disease and immunisation: Standardised case definition & guidelines for data collection, analysis. 2016
- Options for improving effectiveness of rotavirus vaccines in developing countries. 2016
- Parechovirus Encephalitis and Neurodevelopmental Outcomes. 2016
- Preterm birth: Case definition & guidelines for data collection, analysis, and presentation of immunisation safety data. 2016
- Rituximab and protection from vaccine preventable diseases: applying the evidence to pediatric patients. 2016
- Are identity badges and lanyards in pediatrics potentially contaminated with viral pathogens? 2015
- Bacillus Calmette-Guérin (BCG) vaccine adverse events in Victoria, Australia: analysis of reports to an enhanced passive surveillance system. 2015
- Febrile seizures following measles and varicella vaccines in young children in Australia. 2015
- Pediatric anaphylactic adverse events following immunization in Victoria, Australia from 2007 to 2013. 2015
- Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015. 2015
- Surveillance of adverse events following the introduction of 13-valent pneumococcal conjugate vaccine in infants, and comparison with adverse events following 7-valent pneumococcal conjugate vaccine, in Victoria, Australia. 2015
- Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age. 2015
- Genetic characterization of a novel G3P rotavirus strain causing gastroenteritis in 12 year old Australian child. 2014
- Outcomes of childhood asthma to the age of 50 years. 2014
- Rotavirus vaccine timeliness in special care nurseries. 2014
- Changes in the epidemiology of gastroenteritis in a paediatric short stay unit following the introduction of rotavirus immunisation. 2013
- Formal Infectious Diseases Consultations at a Tertiary Pediatric Hospital: A 14 Year Review 2013
- Human papillomavirus vaccine in boys: background rates of potential adverse events 2013
- Immunisation coverage in children with cerebral palsy compared with the general population. 2013
- Improving preterm infants' immunisation status: A follow-up audit. 2013
- International collaboration to assess the risk of Guillain Barré Syndrome following Influenza A (H1N1) 2009 monovalent vaccines. 2013
- Intussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program. 2013
- Paediatric active enhanced disease surveillance: a new surveillance system for Australia. 2013
- Pertussis encephalopathy in an infant. 2013
- Varicella infection in infants less than 12 months. 2013
- Australian immunisation registers: established foundations and opportunities for improvement 2012
- Changes in Patterns of Hospitalized Children with Varicella and of Associated Varicella Genotypes Following Introduction of Varicella Vaccine in Australia. 2012
- Guillain-Barre syndrome following pandemic (H1N1) 2009 influenza A immunisation in Victoria: a self-controlled case series 2012
- Identification of Strains of RotaTeq Rotavirus Vaccine in Infants With Gastroenteritis Following Routine Vaccination 2012
- Influenza vaccination uptake amongst pregnant women and maternal care providers is suboptimal 2012
- Intermittent fever, splenomegaly and eosinophilia in a recently resettled African refugee 2012
- Neurologic complications of influenza A(H1N1)pdm09 Surveillance in 6 pediatric hospitals 2012
- Nosocomial vs community-acquired pandemic influenza A (H1N1) 2009: a nested case-control study 2012
- Prevalence and Characteristics of Human Metapneumovirus Infection Among Hospitalised Children at High Risk for Severe Lower Respiratory Tract Infection 2012
- Recurrent 6th nerve palsy in a child following different live attenuated vaccines: case report 2012
- Surveillance of adverse events following H1N1/09 influenza immunisation in Victoria, Australia 2012
- An australian audit of vaccination status in children and adolescents with inflammatory bowel disease 2011
- Congenital and neonatal varicella: impact of the national varicella vaccination programme in Australia 2011
- Immune Response to Pandemic H1N1 2009 Influenza A Vaccination in Pediatric Liver Transplant Recipients 2011
- Immunizations in an adolescent with inflammatory bowel disease. 2011
- Intussusception following rotavirus vaccine administration: Post-marketing surveillance in the National Immunization Program in Australia 2011
- Optimizing immunization in pediatric special risk groups 2011
- Recurrence of extensive injection site reactions following DTPa or dTpa vaccine in children 4-6 years old 2011
- Recurrent apnoea post immunisation: Informing re-immunisation policy 2011
- Reduction in Rotavirus-associated Acute Gastroenteritis Following Introduction of Rotavirus Vaccine Into Australia's National Childhood Vaccine Schedule 2011
- Syncope and seizures following human papillomavirus vaccination: a retrospective case series 2011
- Victorian Department of Health
- Australian Paediatric Surveillance Unit (APSU)
- Hunter New England Local Health District of New South Wales VaxTracker
- The Royal Children's Hospital
- Monash Health
- The Melbourne Vaccine Education Centre (MVEC)
- National Centre for Immunisation Research and Surveillance (NCIRS)
- Spleen Australia
- Immunisation Branch, OHP, Department Health, Canberra