SAEFVIC (Surveillance of Adverse Events Following Vaccination In the Community) is a public health partnership initiative of the Victorian Immunisation Program funded by the Department of Health, Victoria. It was established in 2007 and is based at the Murdoch Children's Research Institute.
SAEFVIC is a vaccine safety service and clinical immunisation research team, focusing on adverse events following immunisation (AEFI), vaccine-preventable disease research as well as immunisation education.
The initiative is a national leader in vaccine safety, with the SAEFVIC team comprising of immunisation nurses, administrative staff, an epidemiologist, data manager, research staff and clinicians. It is a specialist vaccine safety service that helps immunisation providers report and manage both children and adults who have had an AEFI. Our clinical services are based at The Royal Children's Hospital (Parkville) and Monash Health (Clayton) It also provides regional clinical support via TeleHealth. Any trends in reports are notified and investigated quickly in close liaison with Victorian and National Health Authorities.
SAEFVIC clinical research includes surveillance and drug trials. Surveillance projects include active and passive studies, including involvement in national collaborative networks. This includes annual influenza vaccine safety surveillance (AusVaxSafety), and hospital-based active surveillance of childhood conditions of public health importance through PAEDS (Paediatric Active Enhanced Surveillance). We also have National Health and Medical Research Centre (NHMRC)-funded projects, including vaccine safety research into febrile seizures and special risk groups, and response to pneumococcal vaccines in asplenic patients.
The Melbourne Vaccine Education Centre (MVEC)
MVEC was launched in February 2014. SAEFVIC is a national leader in vaccine education and this project is a collaboration between the Melbourne Children’s campus and Monash Health.
AusVaxSafety is a national enhanced surveillance system to monitor adverse events following immunisation with influenza vaccine in children under five years of age. The Victorian vaccine safety surveillance is coordinated by SAEFVIC. The AusVaxSafety team are using Vaxtracker, a technological monitoring system where the parents/carers of children who have received influenza vaccine as part of good clinical care are offered participation and following consent, parents/carers are sent an SMS message or email three days after vaccination. They are asked to provide information on whether their child experienced any adverse event after vaccination. Each week, data from all parent/carer reports are combined and analysed. Surveillance under AusVaxSafety commenced in March 2014 and up-to-date results on this important vaccine safety initiative are detailed on the website.
AEFI-CAN (Adverse event following immunisation- clinical assessment network)
SAEFVIC is the coordinating centre for this Department of Health funded network currently focusing on HPV adverse events.
PAEDS (Paediatric Active Enhanced Disease Surveillance)
This study uses hospital-based active surveillance to identifying and investigate childhood conditions of public health importance, which are difficult to adequately capture through other surveillance mechanisms. Conditions of interest include: acute flaccid paralysis, encephalitis, intussusception, pertussis and varicella.
PAPI (Protecting asplenic children and adults against pneumococcal disease and identifying optimal immunisation regimens)
This is a multi-centre Phase IV study conducted at MCRI/RCH, Monash Medical Centre, and the Alfred Hospital, supported by an NHMRC project grant.
Febrile Seizures Following vaccination in children: What is the long term clinical and developmental outcome?
This is multi-centre NHMRC funded project conducted at Murdoch Children's and The Royal Children's Hospital; The Epilepsy Research Centre, VIC; The Children’s Hospital at Westmead, NSW; Women’s and Children’s Hospital, SA; Princess Margaret Hospital, WA.
- Allergic adverse events following 2015 seasonal influenza vaccine, Victoria, Australia. 2017
- Evaluation of 'SAEFVIC', A Pharmacovigilance Surveillance Scheme for the Spontaneous Reporting of Adverse Events Following Immunisation in Victoria, Australia. 2017
- Kawasaki disease and immunisation: A systematic review. 2017
- Antenatal pertussis vaccination: Are we implementing best evidence into practice? 2016
- Don't aim too high: Avoiding shoulder injury related to vaccine administration. 2016
- Kawasaki disease and immunisation: Standardised case definition & guidelines for data collection, analysis. 2016
- Options for improving effectiveness of rotavirus vaccines in developing countries. 2016
- Parechovirus Encephalitis and Neurodevelopmental Outcomes. 2016
- Preterm birth: Case definition & guidelines for data collection, analysis, and presentation of immunisation safety data. 2016
- Rituximab and protection from vaccine preventable diseases: applying the evidence to pediatric patients. 2016
- Are identity badges and lanyards in pediatrics potentially contaminated with viral pathogens? 2015
- Bacillus Calmette-Guérin (BCG) vaccine adverse events in Victoria, Australia: analysis of reports to an enhanced passive surveillance system. 2015
- Febrile seizures following measles and varicella vaccines in young children in Australia. 2015
- Pediatric anaphylactic adverse events following immunization in Victoria, Australia from 2007 to 2013. 2015
- Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015. 2015
- Surveillance of adverse events following the introduction of 13-valent pneumococcal conjugate vaccine in infants, and comparison with adverse events following 7-valent pneumococcal conjugate vaccine, in Victoria, Australia. 2015
- Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age. 2015
- Genetic characterization of a novel G3P rotavirus strain causing gastroenteritis in 12 year old Australian child. 2014
- Outcomes of childhood asthma to the age of 50 years. 2014
- Rotavirus vaccine timeliness in special care nurseries. 2014
- Changes in the epidemiology of gastroenteritis in a paediatric short stay unit following the introduction of rotavirus immunisation. 2013
- Formal Infectious Diseases Consultations at a Tertiary Pediatric Hospital: A 14 Year Review 2013
- Human papillomavirus vaccine in boys: background rates of potential adverse events 2013
- Immunisation coverage in children with cerebral palsy compared with the general population. 2013
- Improving preterm infants' immunisation status: A follow-up audit. 2013
- International collaboration to assess the risk of Guillain Barré Syndrome following Influenza A (H1N1) 2009 monovalent vaccines. 2013
- Intussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program. 2013
- Paediatric active enhanced disease surveillance: a new surveillance system for Australia. 2013
- Pertussis encephalopathy in an infant. 2013
- Varicella infection in infants less than 12 months. 2013
- Australian immunisation registers: established foundations and opportunities for improvement 2012
- Changes in Patterns of Hospitalized Children with Varicella and of Associated Varicella Genotypes Following Introduction of Varicella Vaccine in Australia. 2012
- Guillain-Barre syndrome following pandemic (H1N1) 2009 influenza A immunisation in Victoria: a self-controlled case series 2012
- Identification of Strains of RotaTeq Rotavirus Vaccine in Infants With Gastroenteritis Following Routine Vaccination 2012
- Influenza vaccination uptake amongst pregnant women and maternal care providers is suboptimal 2012
- Intermittent fever, splenomegaly and eosinophilia in a recently resettled African refugee 2012
- Neurologic complications of influenza A(H1N1)pdm09 Surveillance in 6 pediatric hospitals 2012
- Nosocomial vs community-acquired pandemic influenza A (H1N1) 2009: a nested case-control study 2012
- Prevalence and Characteristics of Human Metapneumovirus Infection Among Hospitalised Children at High Risk for Severe Lower Respiratory Tract Infection 2012
- Recurrent 6th nerve palsy in a child following different live attenuated vaccines: case report 2012
- Surveillance of adverse events following H1N1/09 influenza immunisation in Victoria, Australia 2012
- An australian audit of vaccination status in children and adolescents with inflammatory bowel disease 2011
- Congenital and neonatal varicella: impact of the national varicella vaccination programme in Australia 2011
- Immune Response to Pandemic H1N1 2009 Influenza A Vaccination in Pediatric Liver Transplant Recipients 2011
- Immunizations in an adolescent with inflammatory bowel disease. 2011
- Intussusception following rotavirus vaccine administration: Post-marketing surveillance in the National Immunization Program in Australia 2011
- Optimizing immunization in pediatric special risk groups 2011
- Recurrence of extensive injection site reactions following DTPa or dTpa vaccine in children 4-6 years old 2011
- Recurrent apnoea post immunisation: Informing re-immunisation policy 2011
- Reduction in Rotavirus-associated Acute Gastroenteritis Following Introduction of Rotavirus Vaccine Into Australia's National Childhood Vaccine Schedule 2011
- Syncope and seizures following human papillomavirus vaccination: a retrospective case series 2011