SAEFVIC (Surveillance of Adverse Events Following Vaccination In the Community) is a public health partnership initiative of the Victorian Immunisation Program funded by the Department of Health, Victoria. It was established in 2007 and now comprises of two units at two sites:
- Clinical - Murdoch Childrens Research Institute.
- Epidemiology and Signal Investigation - Monash Health & University
SAEFVIC is a vaccine safety service and clinical immunisation research team, focusing on vaccine safety and surveillance. This includes management of adverse events following immunisation (AEFI), vaccine-preventable disease research and immunisation education. Most recently, we established the COVID-19 Platform of Research capturing clinical, biological, demographic and administrative data, as well as patient and healthcare worker experiences of COVID-19.
SAEFVIC is a national leader in vaccine safety. The team comprises of immunisation nurses, administrative staff, research staff, an epidemiologist, statistician, data manager and clinicians. It is a specialist vaccine safety service that helps immunisation providers report and manage both children and adults who have had an AEFI. Our Outpatient clinics are based at The Royal Children's Hospital (Parkville) and Monash Health (Clayton). SAEFVIC also provides regional clinical support via TeleHealth. Any trends in reports are notified and investigated quickly in close liaison with Victorian and national health authorities, such as the Therapeutic Goods Adminsitration
SAEFVIC clinical research includes surveillance and clinical studies. Surveillance projects incorporate active and passive studies, including involvement in national collaborative networks, such as the AusVaxSafety and PAEDS (Paediatric Active Enhanced Surveillance) networks. These networks focus on conditions of public health importance and support the National Immunisation Program.
We also have National Health and Medical Research Centre (NHMRC)-funded projects, such as vaccine safety research into febrile seizures. SAEFVIC’s education activities include the Melbourne Vaccine Education Centre.
Research Topic : Vaccine Safety
Project: Surveillance of Adverse Events Following Vaccination In the Community (SAEFVIC)
SAEFVIC is an enhanced passive central reporting service in Victoria for significant adverse events following immunisations (AEFI). It is a public health partnership initiative of the Victorian Immunisation Program funded by the Department of Health, Victoria.
Research Topic: Vaccine Education
Melbourne Vaccine Education Centre (MVEC)
The Melbourne Vaccine Education Centre (MVEC) is an educational website, developed with the aim of providing up-to-date immunisation information for both healthcare professionals and members of the public.
We are based at Murdoch Children’s Research Institute (MCRI), a research organisation, and are affiliated with SAEFVIC (Surveillance of Adverse Events Following Vaccination in the Community), the Victorian Vaccine Safety Service.
The content of MVEC reflects a collaboration of information prepared by immunisation paediatricians and adult physicians, immunisation nurses, infectious disease specialists, allergy specialists and infection control teams. All information is reviewed and updated on a regular basis.
MVEC is a proud member of the World Health Organisation’s (WHO) Vaccine Safety Net. All Vaccine Safety Net members are endorsed by the WHO as a source of reliable and credible vaccine safety information.
MVEC is funded by SAEFVIC and the Victorian Government Department of Health and Human Services (DHHS) Immunisation Section.
Research Topic: COVID-19
1) COVID-19 at the Melbourne Children’s Campus: Program of Research
A prospective observational study capturing clinical, biological, demographic and administrative data, as well as patient and HCW experiences of COVID-19. The primary objective of this project is to establish a platform of research to examine COVID-19 cases identified at RCH, including: epidemiologic, virologic, immunologic, economic and social science perspectives, placed in the context of a global pandemic.
This platform also aims to reduce the burden on participants approached to become involved in COVID-19 studies, by prioritising research objectives and collating baseline data. The ‘Program of Research’ aims to use multiple methodologies to address key unknowns identified by our Melbourne Children’s Campus COVID-19 Research Expert Working Group.
This research will address questions that are of keen interest for national and international public health policy. The primary outcome is the establishment of a Platform for COVID-19 research at the Melbourne Children’s Campus, aiming to address some of the key questions in the paediatric population
2) COVID-Kids Inpatient
A prospective study to examine clinical, demographic, laboratory and outcome data on hospital paediatric patients with COVID-19. It incorporates the Sentinel Travellers and Research Preparedness for Emerging Infectious Diseases (SETREP-ID) study in adults coordinated by the Doherty Institute.
A prospective observational study of COVID-19 transmission and disease course. The study involves a number of different components including contribution of data to the Australian FFX project coordinated through the Peter Doherty Institute as a national study of household transmission.
4) Natural history of SARS-CoV-2 in comparison to influenza A virus: a multi-site study focused in the Southern Hemisphere and equatorial regions
Surveillance for SARS-CoV-2 and influenza virus at eight sites across the Southern Hemisphere and equatorial regions including Australia. Data collected via the COVID-Kids Inpatient and FFX+ studies. This will be compared to patients with influenza infection with the aim to give context to the results obtained and better understand the implications for human health for those affected by COVID-19.
5) COVID-19 (PAEDS Study Arm 11.1)
Part of the National PAEDS network, this is a prospective surveillance study of COVID-19 in children presenting to contributing hospitals nationally. This study aims to describe the demographic and clinical features of COVID-19 in children in Australia; estimate the hospitalisation rate of COVId-19 in children using sentinel site data in Australia; collect internationally comparable data for potential future data sharing to enable higher powered analyses of COVID-19 in children.
6) PIMS-TS (PAEDS Study Arm 12)
As part of the National PAEDS network, this is a prospective surveillance study of PIMS-TS in children admitted to PAEDS network hospitals. The main aims of this study are to: To describe the demographic and clinical features of PIMS-TS in children and adolescents admitted to PAEDS network hospitals; to estimate the incidence and further characterise the aetiology of PIMS-TS in Australia; to determine the overlapping features of PIMS-TS with Kawasaki disease and COVID-19 in Australian children; to collect internationally comparable data for potential future data sharing to enable higher powered analysis of PIMS-TS in children and adolescents.
7) Serosurvey (PAEDS Study Arm 11.3)
Part of the National PAEDS network, this is a direct and targeted sampling study of well paediatric patients admitted to The Royal Children’s Hospital for an anaesthetic procedure. The aim is to gain an understanding of what proportion of the Australian population has or may have been exposed to COVID-19.
8) Saliva for diagnosis of COVID-19 in primary care, paediatric and out-of-hospital settings (The SPIT-C19 study)
This study aims to find out whether using saliva to diagnose COVID-19 is as reliable as a nose and throat swab by comparing these two tests.
9) Best Available Treatment for Paediatric Inflammatory Syndromes Temporally Associated with SARS-CoV-2.
International registry with the aim to:
- Understand the complete clinical spectrum of presenting signs and symptoms of children with PIMS-TS
- Describe the clinical course and the risk of disease progression of children with PIMS-TS
- Evaluate which treatments are being used worldwide to treat patients with PIMS-TS, and to monitor the response to any immunomodulatory drugs given.
- Provide best care recommendations on treatment options in children with PIMS-TS with varying severity and multiorgan involvement
Research Topic: Influenza
PAEDS Study Arm 6: The Influenza Complications Alert Network (FluCAN) Surveillance system.
A case control study of patients hospitalised with confirmed influenza, matched to control patients hospitalised with acute respiratory infections who test negative for influenza. The primary aim is to estimate vaccine effectiveness again hospitalisation with confirmed influenza. This study contributes to the National FluCAN network coordinated by the Alfred Hospital, Melbourne.
- National Health and Medical Research Council
- Commonwealth Department of Health, Immunisation Branch
- Victorian DHHS, Immunisation branch
- National Institute of Health (NIH)
- WHO Influenza collaborating centre (Doherty, UoM)
- Monash University
- The Alfred Hospital
- PAEDS group
- The Children’s Hospital Westmead, NSW
- Women’s and Children’s Hospital, SA
- Queensland Children’s Hospital, QLD
- Royal Darwin Hospital, NT
- Perth Children’s Hospital, WA
- Monash Children’s Hospital, VIC
- Assessing the quality of care for children attending health facilities: a systematic review of assessment tools. 2021
- Changing Epidemiology of Respiratory Syncytial Virus in Australia - delayed re-emergence in Victoria compared to WA/NSW after prolonged lock-down for COVID-19. 2021
- Persistence of SARS-CoV-2-Specific IgG in Children 6 Months After Infection, Australia. 2021
- Subcutaneous nodule at the vaccine injection site - A case of mistaken identity. 2021
- The use of dried blood spots for the serological evaluation of SARS-CoV-2 antibodies. 2021
- Blistering post 4-year old Infanrix® IPV. 2020
- Developmental outcomes following vaccine-proximate febrile seizures in children. 2020
- Disparities in parental awareness of children's seasonal influenza vaccination recommendations and influencers of vaccination. 2020
- Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19. 2020
- Impact of Australian mandatory 'No Jab, No Pay' and 'No Jab, No Play' immunisation policies on immunisation services, parental attitudes to vaccination and vaccine uptake, in a tertiary paediatric hospital, the Royal Children's Hospital, Melbourne. 2020
- One disease, two vaccines: challenges in prevention of meningococcal disease. 2020
- Paediatric Active Enhanced Disease Surveillance (PAEDS) 2017 and 2018: Prospective hospital-based surveillance for serious paediatric conditions. 2020
- SAEFVIC: Surveillance of adverse events following immunisation (AEFI) in Victoria, Australia, 2018. 2020
- Safety of meningococcal B vaccine (4CMenB) in adolescents in Australia. 2020
- Safety of the Polish BCG-10 Vaccine During a Period of BCG Vaccine Shortage: An Australian Experience. 2020
- SARS-CoV-2 testing and outcomes in the first 30 days after the first case of COVID-19 at an Australian children's hospital. 2020
- SCN1A Variants in vaccine-related febrile seizures: A prospective study. 2020
- Seasonal influenza vaccination for children with special risk medical conditions: Does policy meet practice? 2020
- Subcutaneous nodules following immunization in children; in Victoria, Australia from 2007 to 2016. 2020
- The impact of new universal child influenza programs in Australia: Vaccine coverage, effectiveness and disease epidemiology in hospitalised children in 2018. 2020
- Update on the COVID-19-associated inflammatory syndrome in children and adolescents; paediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2. 2020
- Are children with special risk medical conditions receiving influenza vaccination? Validity of parental and provider report, and to a National Immunisation Register. 2019
- Clinical characteristics, predictors, and performance of case definition-Interim results from the WHO global respiratory syncytial virus surveillance pilot. 2019
- Influenza Epidemiology, Vaccine Coverage and Vaccine Effectiveness in Children Admitted to Sentinel Australian Hospitals in 2017: Results from the PAEDS-FluCAN Collaboration. 2019
- Influenza in Children With Special Risk Medical Conditions: A Systematic Review and Meta-analysis. 2019
- Invasive group A Streptococcus disease in Australian children: 2016 to 2018 - a descriptive cohort study. 2019
- Postvaccination Febrile Seizure Severity and Outcome. 2019
- Distribution of Bacillus Calmette-Guérin (BCG) Vaccine in Victoria 2013-2015. 2018
- Influenza vaccination: Uptake and associations in a cross-sectional study of children with special risk medical conditions. 2018
- Recurrence risk of a hypotonic hyporesponsive episode in two Australian specialist immunisation clinics. 2018
- Respiratory virus detection and co-infection in children and adults in a large Australian hospital in 2009-2015. 2018
- Splenic cyst and its management in a 21-month-old boy: a rare complication of invasive meningococcal disease. 2018
- Vaccine Update: Recent Progress With Novel Vaccines, and New Approaches to Safety Monitoring and Vaccine Shortage. 2018
- Adverse events following vaccination of older people may be under-reported. 2017
- Allergic adverse events following 2015 seasonal influenza vaccine, Victoria, Australia. 2017
- An increase in accident and emergency presentations for adverse events following immunisation after introduction of the group B meningococcal vaccine: an observational study. 2017
- Association Between Prenatal Alcohol Exposure and Craniofacial Shape of Children at 12 Months of Age. 2017
- Bradycardia and Hypothermia Complicating Azithromycin Treatment. 2017
- Evaluation of 'SAEFVIC', A Pharmacovigilance Surveillance Scheme for the Spontaneous Reporting of Adverse Events Following Immunisation in Victoria, Australia. 2017
- External Validation of Six Pediatric Fever and Neutropenia Clinical Decision Rules. 2017
- Failure to thrive: Case definition & guidelines for data collection, analysis, and presentation of maternal immunisation safety data. 2017
- Influenza-associated Encephalitis/Encephalopathy Identified by the Australian Childhood Encephalitis Study 2013-2015. 2017
- Kawasaki disease and immunisation: A systematic review. 2017
- Prospective Surveillance of Pediatric Invasive Group A Streptococcus Infection. 2017
- The Spectrum and Burden of Influenza-Associated Neurological Disease in Children: Combined Encephalitis and Influenza Sentinel Site Surveillance from Australia 2013-2015. 2017
- The Spectrum and Burden of Influenza-Associated Neurological Disease in Children: Combined Encephalitis and Influenza Sentinel Site Surveillance From Australia, 2013-2015. 2017
- Adverse events following HPV immunization in Australia: Establishment of a clinical network. 2016
- Antenatal pertussis vaccination: Are we implementing best evidence into practice? 2016
- Don't aim too high: Avoiding shoulder injury related to vaccine administration. 2016
- Interesting microorganism. 2016
- Kawasaki disease and immunisation: Standardised case definition & guidelines for data collection, analysis. 2016
- Options for improving effectiveness of rotavirus vaccines in developing countries. 2016
- Parechovirus Encephalitis and Neurodevelopmental Outcomes. 2016
- Parechovirus Encephalitis and Neurodevelopmental Outcomes. 2016
- Preterm birth: Case definition & guidelines for data collection, analysis, and presentation of immunisation safety data. 2016
- Rituximab and protection from vaccine preventable diseases: applying the evidence to pediatric patients. 2016
- Are identity badges and lanyards in pediatrics potentially contaminated with viral pathogens? 2015
- Bacillus Calmette-Guérin (BCG) vaccine adverse events in Victoria, Australia: analysis of reports to an enhanced passive surveillance system. 2015
- Febrile seizures following measles and varicella vaccines in young children in Australia. 2015
- Pediatric anaphylactic adverse events following immunization in Victoria, Australia from 2007 to 2013. 2015
- Real-time safety surveillance of seasonal influenza vaccines in children, Australia, 2015. 2015
- Surveillance of adverse events following the introduction of 13-valent pneumococcal conjugate vaccine in infants, and comparison with adverse events following 7-valent pneumococcal conjugate vaccine, in Victoria, Australia. 2015
- Timing of routine infant vaccinations and risk of food allergy and eczema at one year of age. 2015
- Genetic characterization of a novel G3P rotavirus strain causing gastroenteritis in 12 year old Australian child. 2014
- Outcomes of childhood asthma to the age of 50 years. 2014
- Rotavirus vaccine timeliness in special care nurseries. 2014
- The safety of seasonal influenza vaccines in Australian children in 2013. 2014
- Changes in the epidemiology of gastroenteritis in a paediatric short stay unit following the introduction of rotavirus immunisation. 2013
- Formal Infectious Diseases Consultations at a Tertiary Pediatric Hospital: A 14 Year Review 2013
- Human papillomavirus vaccine in boys: background rates of potential adverse events 2013
- Immunisation coverage in children with cerebral palsy compared with the general population. 2013
- Improving preterm infants' immunisation status: A follow-up audit. 2013
- International collaboration to assess the risk of Guillain Barré Syndrome following Influenza A (H1N1) 2009 monovalent vaccines. 2013
- Intussusception risk and disease prevention associated with rotavirus vaccines in Australia's National Immunization Program. 2013
- Paediatric active enhanced disease surveillance: a new surveillance system for Australia. 2013
- Pertussis encephalopathy in an infant. 2013
- Varicella infection in infants less than 12 months. 2013
- Australian immunisation registers: established foundations and opportunities for improvement 2012
- Changes in Patterns of Hospitalized Children with Varicella and of Associated Varicella Genotypes Following Introduction of Varicella Vaccine in Australia. 2012
- Guillain-Barre syndrome following pandemic (H1N1) 2009 influenza A immunisation in Victoria: a self-controlled case series 2012
- Identification of Strains of RotaTeq Rotavirus Vaccine in Infants With Gastroenteritis Following Routine Vaccination 2012
- Influenza vaccination uptake amongst pregnant women and maternal care providers is suboptimal 2012
- Intermittent fever, splenomegaly and eosinophilia in a recently resettled African refugee 2012
- Neurologic complications of influenza A(H1N1)pdm09 Surveillance in 6 pediatric hospitals 2012
- Nosocomial vs community-acquired pandemic influenza A (H1N1) 2009: a nested case-control study 2012
- Prevalence and Characteristics of Human Metapneumovirus Infection Among Hospitalised Children at High Risk for Severe Lower Respiratory Tract Infection 2012
- Recurrent 6th nerve palsy in a child following different live attenuated vaccines: case report 2012
- Surveillance of adverse events following H1N1/09 influenza immunisation in Victoria, Australia 2012
- An australian audit of vaccination status in children and adolescents with inflammatory bowel disease 2011
- Congenital and neonatal varicella: impact of the national varicella vaccination programme in Australia 2011
- Immune Response to Pandemic H1N1 2009 Influenza A Vaccination in Pediatric Liver Transplant Recipients 2011
- Immunizations in an adolescent with inflammatory bowel disease. 2011
- Intussusception following rotavirus vaccine administration: Post-marketing surveillance in the National Immunization Program in Australia 2011
- Optimizing immunization in pediatric special risk groups 2011
- Recurrence of extensive injection site reactions following DTPa or dTpa vaccine in children 4-6 years old 2011
- Recurrent apnoea post immunisation: Informing re-immunisation policy 2011
- Reduction in Rotavirus-associated Acute Gastroenteritis Following Introduction of Rotavirus Vaccine Into Australia's National Childhood Vaccine Schedule 2011
- Syncope and seizures following human papillomavirus vaccination: a retrospective case series 2011